Adsunib 12.5 Capsule

Reviews How to Use Benefits Uses Side Effects

Product Info

Prescription required	Yes
Marketer	Adley Formulations
Active Ingredient	Sunitinib (12.5mg)
Storage	Store below 30°C
Chemical Class	Indole and Pyrrole Derivative
Habit Forming	No
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Tyrosine kinase inhibitors
User Rating	4.3
User Reviews	608

FAQ

Does Adsunib 12.5 have any effect on blood sugar levels in diabetics?

Yes, Adsunib 12.5 may decrease your blood sugar levels. Therefore, if you are a diabetic, you need to be extra careful since your blood sugar levels may become so low that you may become unconscious. Keep a regular check on the blood sugar levels, based on which your dose of anti-diabetics may be changed.

Can Adsunib 12.5 cause any change in blood pressure?

Generally, Adsunib 12.5 is known to cause an increase in blood pressure. Therefore, it is important that you keep a regular check on your blood pressure levels. Inform your doctor if you have severe headache, dizziness, lightheadedness or change in vision. Your doctor may prescribe a medicine to treat the increase blood pressure or may stop your treatment temporarily till your blood pressure returns to normal.

Are generics available for Adsunib 12.5? How does Adsunib 12.5 work?

There are no generics available for Adsunib 12.5. Adsunib 12.5 blocks an enzyme which promotes the growth and spread of cancer cells. This enzyme is called protein kinase and is present on the surface of cancer cells. Blocking this enzyme stops the spread of cancer. Examples of other protein kinase inhibitors are erlotinib, gefitinib, lapatinib, vemurafenib and dasatinib.

Does Adsunib 12.5 have any effect on skin and hair?

During treatment with Adsunib 12.5, your skin may get lighter and there may be hair loss. Also, patient may experience dryness, thickness or cracking of the skin, blisters, or rashes on the palms and soles. But, these side effects are reversible and go away once the medicine is stopped. Adsunib 12.5 may also cause serious skin reactions such as severe rash or rapidly spreading skin ulceration which could be fatal. Therefore, inform your doctor immediately if symptoms of infection occur around a skin injury. Let your doctor know if you have fever, pain, redness, swelling, or drainage of pus or blood.

How should I take Adsunib 12.5?

You should take Adsunib 12.5 exactly as directed by your doctor. It should be started by doctors who have experience in administering cancer medicines. Take it once a day with or without food. Do not drink grapefruit juice or eat grapefruit during your treatment with Adsunib 12.5, as the chances of side effects may be more.

What is the most important thing I need to know about Adsunib 12.5?

Adsunib 12.5 can cause serious side effects such as severe liver problems that can lead to death. Therefore, tell your doctor right away if you experience itching, yellow eyes or skin, dark urine or pain or discomfort in the right upper stomach area. Your doctor will get blood tests done to check your liver function before and during treatment with Adsunib 12.5. In case you develop liver problems, your doctor may stop the medicine temporarily or permanently.

Can Adsunib 12.5 be used in combination with other chemotherapy medicines?

There are no studies that support the use of Adsunib 12.5 with other chemotherapy medicines. For example, Adsunib 12.5 is used in Gastrointestinal stromal tumour (GIST), a type of cancer of the stomach and bowel, when imatinib (another anticancer medicine) no longer works or the patient cannot take imatinib.

What if you forget to take Adsunib Capsule?

If you miss a dose of Adsunib 12.5, skip it and continue with your normal schedule. Do not double the dose.

Adsunib 12.5 Capsule Reviews

Adsunib 12.5 is a medicine used in the treatment of kidney cancer and gastrointestinal stromal tumor. It works by blocking specific enzymes that promote the growth of cancer cells. This way it shrinks the tumor and slows down its progression.

Adsunib 12.5 can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Common side effects of this medicine include weakness, diarrhea, nausea, vomiting, taste change, and decreased appetite. The doctor may advise for regular monitoring of blood pressure and thyroid gland function while taking this medicine. It may decrease blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, if you are diabetic then it is important to check your blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or bleeding disorder. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

How Adsunib 12.5 Capsule Works

Adsunib 12.5 is an anti-cancer medication. It works by binding and blocking certain cell surface protein (tyrosine kinase) responsible for the propagation of cancer growth. It also restricts the growth of new blood vessels within the tumor. This is how it prevents the proliferation of malignant cancers.

How to Use Adsunib 12.5 Capsule

Take this medicine in the dose and duration as advised by your doctor. Adsunib 12.5 may be taken with or without food, but it is better to take it at a fixed time.

Benefits of Adsunib 12.5 Capsule

In Treatment of Gastrointestinal stromal tumour: A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most commonly in the stomach or small intestine. The tumors develop into the specialized cells called interstitial cells of Cajal (ICCs). Adsunib 12.5 helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor’s instructions carefully to get the most benefit.
In Treatment of Kidney cancer: Adsunib 12.5 is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

Uses of Adsunib 12.5 Capsule

Treatment of Kidney cancer
Treatment of Gastrointestinal stromal tumour

Adsunib 12.5 Capsule Side Effects

Safety Tips

Kidney ^{SAFE IF PRESCRIBED}

Adsunib 12.5 is safe to use in patients with kidney disease. No dose adjustment of Adsunib 12.5 is recommended.

Alcohol ^{CONSULT YOUR DOCTOR}

It is not known whether it is safe to consume alcohol with Adsunib 12.5. Please consult your doctor.

Liver ^{SAFE IF PRESCRIBED}

Adsunib 12.5 is safe to use in patients with liver disease. No dose adjustment of Adsunib 12.5 is recommended.

Driving ^UNSAFE

Adsunib 12.5 may cause side effects which could affect your ability to drive.Adsunib 12.5 may cause dizziness during the treatment. Do not drive or operate machineries if you experience this while on treatment with the medicine.

Pregnancy ^{CONSULT YOUR DOCTOR}

Adsunib 12.5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding ^{CONSULT YOUR DOCTOR}

Adsunib 12.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Quick Tips

In case you need to undergo any surgical procedure, ensure to inform the doctor about your use of Adsunib 12.5.
It may affect wound healing time. Be careful while shaving, cutting fingernails or toenails, or using sharp objects.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitoring of thyroid gland function is required while taking this medicine. Inform your doctor if you notice symptoms of weight gain, dry skin, and hair.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1740.
Sunitinib malate. Sandwich, Kent: Pfizer Limited; 2006 [revised Feb. 2019].
Central Drugs Standard Control Organisation (CDSCO).
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1304.
Sunitinib malate [Prescribing Information]. New York, New York: Pfizer Inc.; 2021.