Amphotret 50mg Injection

Product Info

FAQ

What is Amphotret 50mg liposomal?

Liposomal Amphotret 50mg is a lipid-associated formulation. Liposomal encapsulation or incorporation into a lipid complex of Amphotret 50mg can substantially improves drug safety especially nephrotoxicity associated with the drug

Is Amphotret 50mg an antibiotic?

Yes, Amphotret 50mg is an antifungal antibiotic for the treatment of serious infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite)

How does Amphotret 50mg cause nephrotoxicity and hyperkalemia?

Amphotret 50mg can disrupt the lipid components of human kidney cells, thereby causing nephrotoxicity. The exact mechanism of hypokalemia is not known, but kidney damage may result in excessive loss of potassium in urine.

Is Amphotret 50mg light sensitive?

Amphotret 50mg is not light sensitive

How is Amphotret 50mg administered?

Amphotret 50mg is either administered as intravenous injection or infusion by a registered medical professional only

Is Amphotret 50mg testing dose needed?

Yes, administration of Amphotret 50mg is associated with allergy (severe and serious allergic) reaction, therefore it is recommended to administer a test dose before starting the therapy to check for sensitivity

Is Amphotret 50mg fungistatic or fungicidal?

Amphotret 50mg is fungicidal in nature, it acts by killing the fungus

What if you forget to take Amphotret Injection?

If you miss a dose of Amphotret 50mg, please consult your doctor.

Amphotret 50mg Injection Reviews

How Amphotret 50mg Injection Works

How to Use Amphotret 50mg Injection

Benefits of Amphotret 50mg Injection

• In Kala-azar: Kala azar is a disease caused by leishmania parasites mainly by the bite of infected sandflies. Amphotret 50mg helps to kill the infection causing parasites and helps to treat the infection. This medicine is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the parasites are killed and do not become resistant.
• In Severe fungal infections: Amphotret 50mg works by killing the fungi which can cause serious infections. It is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the fungi and yeast causing the infection are killed and do not become resistant.

Uses of Amphotret 50mg Injection

• Kala-azar
• Severe fungal infections

Amphotret 50mg Injection Side Effects

• Abnormal renal function tests
• Vomiting
• Chills
• Nausea
• Abnormal liver function tests
• Diarrhea
• Decreased potassium level in blood
• Decreased appetite
• Hypotension (low blood pressure)
• Decreased magnesium level in blood
• Renal tubular acidosis
• Nephrocalcinosis
• Skin rash
• Headache
• Increased creatinine level in blood
• Anemia (low number of red blood cells)
• Injection site reactions (pain, swelling, redness)

Safety Tips

Quick Tips

• It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
• Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium and kidney function.
• Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face and trouble breathing.
• Amphotret 50mg can cause rash, chills, headache, and tiredness during initial days of the treatment, but these may fade away with time.
• Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. 

References

1. Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 836-38.
2. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004; 80(5):4-6.
3. Amphotericin B. San Dimas, California: Gilead Sciences, Inc.; 2000.
4. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
5. Central Drugs Standard Control Organisation (CDSCO).
6. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 68-69.
7. Medsacpe. Amphotericin.
8. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.

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