Avastimab 400mg Injection
Product Info
| Prescription required | Yes |
| Marketer | RPG Life Sciences Ltd |
| Active Ingredient | Bevacizumab (400mg) |
| Storage | Store in a refrigerator (2 - 8°C). Do not freeze. |
| Chemical Class | Monoclonal antibody (mAb) |
| Habit Forming | No |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Vascular endothelial growth factor (VEGF) inhibitor |
| User Rating | 4.2 |
| User Reviews | 365 |
FAQ
What kinds of cancer can Avastimab 400mg be used for ?
Avastimab 400mg is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).
How long can I take Avastimab 400mg for?
You keep taking Avastimab 400mg as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Avastimab 400mg. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.
Does a person taking Avastimab 400mg still need chemotherapy?
Chemotherapy is still needed along with taking Avastimab 400mg. It makes chemotherapy work better.
How is Avastimab 400mg given?
Avastimab 400mg is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.
How Avastimab 400mg works differently from chemotherapy?
Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Avastimab 400mg is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.
What if you forget to take Avastimab Injection?
If you miss a dose of Avastimab 400mg, please consult your doctor.
Avastimab 400mg Injection Reviews
Avastimab 400mg is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.
Avastimab 400mg is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Avastimab 400mg as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.
The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.
Avastimab 400mg is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Avastimab 400mg as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.
The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.
How Avastimab 400mg Injection Works
Avastimab 400mg is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.
How to Use Avastimab 400mg Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Uses of Avastimab 400mg Injection
- Cancer of colon and rectum
- Brain tumor
- Kidney cancer
- Ovarian cancer
- Non-small cell lung cancer
- Cervical cancer
Avastimab 400mg Injection Side Effects
- Wound healing complications
- Hypersensitivity
- Exfoliative dermatitis
- Electrolyte imbalance
- Mucosal inflammation
- Ovarian failure
- Rectovaginal fistula
- Decreased white blood cell count (lymphocytes)
- Thromboembolism
- High blood pressure
- Decreased appetite
- Abscess
- Breathlessness
- Cellulitis
- Low blood platelets
- Protein in urine
- Peripheral sensory neuropathy
- Nosebleeds
Safety Tips
Breast feeding
CONSULT YOUR DOCTOR
Avastimab 400mg is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Liver
SAFE IF PRESCRIBED
Avastimab 400mg is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Avastimab 400mg may not be needed in these patients. Please consult your doctor.
Kidney
SAFE IF PRESCRIBED
Avastimab 400mg is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Avastimab 400mg may not be needed in these patients. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Avastimab 400mg may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Avastimab 400mg. Please consult your doctor.
Driving
UNSAFE
Avastimab 400mg may cause side effects which could affect your ability to drive.Sleepiness and fainting have been reported with Avastimab 400mg and this may impair your ability to drive.
Quick Tips
- It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
- It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
- Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Avastimab 400mg.
- Avastimab 400mg is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
- Avastimab 400mg is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
- Avastimab 400mg is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
- It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
- Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Avastimab 400mg.
- Avastimab 400mg is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
- It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
References
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20].
- Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011].
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.