Denoci-OP Injection

Reviews How to Use Benefits Uses Side Effects

Product Info

Prescription required	Yes
Marketer	Cipla Ltd
Active Ingredient	Denosumab (60mg)
Storage	Store in a refrigerator (2 - 8°C). Do not freeze.
Chemical Class	Monoclonal antibody (mAb)
Habit Forming	No
Therapeutic Class	PAIN ANALGESICS
Action Class	Bone resorption inhibitors- Monoclonal antibodies
User Rating	4.6
User Reviews	679

FAQ

How long can you stay on Denoci-OP?

There is no optimal duration of treatment of osteoporosis with Denoci-OP. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denoci-OP. Depending on this, the duration of taking Denoci-OP is decided.

How should Denoci-OP be stored?

Denoci-OP should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

How is Denoci-OP given and how often?

Denoci-OP is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denoci-OP.

Is Denoci-OP a chemotherapy drug?

Denoci-OP is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denoci-OP makes the bones stronger and less likely to break.

Does Denoci-OP cause hair loss?

Yes, hair loss is a common side effect of Denoci-OP though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Can Denoci-OP be taken during pregnancy?

No, pregnant women should not take Denoci-OP. You must use an effective method of birth control during and for at least 5 months after the last dose of Denoci-OP if you can become pregnant.

Does Denoci-OP cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denoci-OP. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denoci-OP. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

What if you forget to take Denoci-OP?

If you miss a dose of Denoci-OP, please consult your doctor.

Denoci-OP Injection Reviews

Denoci-OP is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

Denoci-OP is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

How Denoci-OP Injection Works

Denoci-OP is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

How to Use Denoci-OP Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Benefits of Denoci-OP Injection

In Osteoporosis: Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Denoci-OP slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Uses of Denoci-OP Injection

Osteoporosis

Denoci-OP Injection Side Effects

Safety Tips

Driving ^SAFE

Denoci-OP does not usually affect your ability to drive.

Pregnancy ^UNSAFE

Denoci-OP is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Alcohol ^CAUTION

Caution is advised when consuming alcohol with Denoci-OP. Please consult your doctor.

Kidney ^CAUTION

Denoci-OP should be used with caution in patients with severe kidney disease. Dose adjustment of Denoci-OP may be needed. Please consult your doctor.

Breast feeding ^{CONSULT YOUR DOCTOR}

Denoci-OP is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Liver ^CAUTION

Denoci-OP should be used with caution in patients with severe liver disease. Dose adjustment of Denoci-OP may be needed. Please consult your doctor.

Quick Tips

Do not take if you are pregnant or plan to become pregnant.
Take calcium and vitamin D to help build your bones when taking Denoci-OP.
Tell your doctor if you develop a rash while taking Denoci-OP.
Denoci-OP is a medication used to treat thinning of the bones (called osteoporosis).
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denoci-OP may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Drugs.com. Denosumab.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013.
Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018].