Denorange Injection
Product Info
| Prescription required | Yes |
| Marketer | Biorange Biologicals Private Limited |
| Active Ingredient | Denosumab (60mg/ml) |
| Storage | Store in a refrigerator (2 - 8°C). Do not freeze. |
| Chemical Class | Monoclonal antibody (mAb) |
| Habit Forming | No |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Bone resorption inhibitors- Monoclonal antibodies |
| User Rating | 4.8 |
| User Reviews | 366 |
FAQ
Can Denorange be taken during pregnancy?
No, pregnant women should not take Denorange. You must use an effective method of birth control during and for at least 5 months after the last dose of Denorange if you can become pregnant.
How long can you stay on Denorange?
There is no optimal duration of treatment of osteoporosis with Denorange. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denorange. Depending on this, the duration of taking Denorange is decided.
Does Denorange cause hair loss?
Yes, hair loss is a common side effect of Denorange though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
Is Denorange a chemotherapy drug?
Denorange is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denorange makes the bones stronger and less likely to break.
How is Denorange given and how often?
Denorange is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denorange.
Does Denorange cause osteonecrosis of the jaw?
Osteonecrosis is a rare side effect of Denorange. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denorange. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
How should Denorange be stored?
Denorange should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
What if you forget to take Denorange?
If you miss a dose of Denorange, please consult your doctor.
Denorange Injection Reviews
Denorange is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.
Denorange is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.
Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.
How Denorange Injection Works
Denorange is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
How to Use Denorange Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Benefits of Denorange Injection
- In Osteoporosis: Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Denorange slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.
Uses of Denorange Injection
- Osteoporosis
Denorange Injection Side Effects
Safety Tips
Alcohol
CAUTION
Caution is advised when consuming alcohol with Denorange. Please consult your doctor.
Kidney
CAUTION
Denorange should be used with caution in patients with severe kidney disease. Dose adjustment of Denorange may be needed. Please consult your doctor.
Pregnancy
UNSAFE
Denorange is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Driving
SAFE
Denorange does not usually affect your ability to drive.
Liver
CAUTION
Denorange should be used with caution in patients with severe liver disease. Dose adjustment of Denorange may be needed. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Denorange is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Quick Tips
- Denorange is a medication used to treat thinning of the bones (called osteoporosis).
- May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
- Tell your doctor if you develop a rash while taking Denorange.
- Do not take if you are pregnant or plan to become pregnant.
- Denorange may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
- Take calcium and vitamin D to help build your bones when taking Denorange.
References
- Drugs.com. Denosumab.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
- Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
- Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
- Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013.
- Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018].