Denub 60mg Injection
Product Info
| Prescription required | Yes |
| Marketer | Alkem Laboratories Ltd |
| Active Ingredient | Denosumab (60mg) |
| Storage | Store in a refrigerator (2 - 8°C). Do not freeze. |
| Chemical Class | Monoclonal antibody (mAb) |
| Habit Forming | No |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Bone resorption inhibitors- Monoclonal antibodies |
| User Rating | 4.5 |
| User Reviews | 621 |
FAQ
How is Denub 60mg given and how often?
Denub 60mg is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denub 60mg.
Can Denub 60mg be taken during pregnancy?
No, pregnant women should not take Denub 60mg. You must use an effective method of birth control during and for at least 5 months after the last dose of Denub 60mg if you can become pregnant.
Does Denub 60mg cause osteonecrosis of the jaw?
Osteonecrosis is a rare side effect of Denub 60mg. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denub 60mg. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
Is Denub 60mg a chemotherapy drug?
Denub 60mg is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denub 60mg makes the bones stronger and less likely to break.
How should Denub 60mg be stored?
Denub 60mg should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
How long can you stay on Denub 60mg?
There is no optimal duration of treatment of osteoporosis with Denub 60mg. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denub 60mg. Depending on this, the duration of taking Denub 60mg is decided.
Does Denub 60mg cause hair loss?
Yes, hair loss is a common side effect of Denub 60mg though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
What if you forget to take Denub Injection?
If you miss a dose of Denub 60mg, please consult your doctor.
Denub 60mg Injection Reviews
Denub 60mg is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.
Denub 60mg is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.
Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.
How Denub 60mg Injection Works
Denub 60mg is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
How to Use Denub 60mg Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Benefits of Denub 60mg Injection
- In Osteoporosis: Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Denub 60mg slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.
Uses of Denub 60mg Injection
- Osteoporosis
Denub 60mg Injection Side Effects
Safety Tips
Liver
CAUTION
Denub 60mg should be used with caution in patients with severe liver disease. Dose adjustment of Denub 60mg may be needed. Please consult your doctor.
Driving
SAFE
Denub 60mg does not usually affect your ability to drive.
Alcohol
CAUTION
Caution is advised when consuming alcohol with Denub 60mg. Please consult your doctor.
Kidney
CAUTION
Denub 60mg should be used with caution in patients with severe kidney disease. Dose adjustment of Denub 60mg may be needed. Please consult your doctor.
Pregnancy
UNSAFE
Denub 60mg is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
CONSULT YOUR DOCTOR
Denub 60mg is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Quick Tips
- May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
- Take calcium and vitamin D to help build your bones when taking Denub 60mg.
- Denub 60mg may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
- Denub 60mg is a medication used to treat thinning of the bones (called osteoporosis).
- Do not take if you are pregnant or plan to become pregnant.
- Tell your doctor if you develop a rash while taking Denub 60mg.
References
- Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
- Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
- Drugs.com. Denosumab.
- Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018].
- Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.