Proluton Depot 250mg/ml Injection
Product Info
| Prescription required | Yes |
| Marketer | Zydus Cadila |
| Active Ingredient | Hydroxyprogesterone (250mg/ml) |
| Storage | Store below 25°C |
| Chemical Class | Gluco/Mineralocorticoids, Progestogins Derivatives |
| Habit Forming | No |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Progestins (First generation) |
| User Rating | 4.9 |
| User Reviews | 547 |
FAQ
What is Proluton Depot 250mg/ml? What is it used for?
Proluton Depot 250mg/ml is a type of female sex hormone called progesterone. It helps to lower the risk of preterm delivery (early birth) in a pregnant woman, who had delivered a preterm baby in the past.
What if I miss a dose of Proluton Depot 250mg/ml?
Ideally, you should try not to miss any dose. However, if you miss a dose consult with your doctor as soon as you remember.
Who should not receive Proluton Depot 250mg/ml?
Proluton Depot 250mg/ml should not be used if you have:
-blood clots or other blood clotting problems now or in the past
-high blood pressure that is not controlled
-liver problems, including liver tumors
-breast cancer or other hormone-sensitive cancers now or in the past
-unusual vaginal bleeding not related to your current pregnancy
-yellowing of your skin due to liver problems during your pregnancy.
-blood clots or other blood clotting problems now or in the past
-high blood pressure that is not controlled
-liver problems, including liver tumors
-breast cancer or other hormone-sensitive cancers now or in the past
-unusual vaginal bleeding not related to your current pregnancy
-yellowing of your skin due to liver problems during your pregnancy.
How and in what dose should I use Proluton Depot 250mg/ml?
Proluton Depot 250mg/ml is given as an injection, by a doctor or trained nurse. The dose will be decided by your doctor, depending on your exact medical condition.
What if you forget to take Proluton Depot Injection?
If you miss a dose of Proluton Depot 250mg/ml, please consult your doctor.
Proluton Depot 250mg/ml Injection Reviews
Proluton Depot 250mg/ml is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lowers the risk of premature birth in women who have had one premature delivery in the past.
Proluton Depot 250mg/ml is administered only by or under the supervision of a doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you.
The most common side effects of this medicine include local site reactions at the injection site, nausea, itching, diarrhea, and rash. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may affect blood sugar levels, so monitor your blood sugar regularly. It is better to inform the doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain while using this medicine.
Before taking this medicine inform doctor, if you have ever had any problems with your blood circulation or have diabetes, or any liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
Proluton Depot 250mg/ml is administered only by or under the supervision of a doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you.
The most common side effects of this medicine include local site reactions at the injection site, nausea, itching, diarrhea, and rash. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may affect blood sugar levels, so monitor your blood sugar regularly. It is better to inform the doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain while using this medicine.
Before taking this medicine inform doctor, if you have ever had any problems with your blood circulation or have diabetes, or any liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
How Proluton Depot 250mg/ml Injection Works
Proluton Depot 250mg/ml is a progestin (female hormone).
How to Use Proluton Depot 250mg/ml Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Benefits of Proluton Depot 250mg/ml Injection
- In Prevention of Premature Labor: Proluton Depot 250mg/ml is a man-made form of the female hormone called progesterone, that helps lower the risk of delivering the baby too early (premature labor), particularly in women who have had this complication in an earlier pregnancy. Progesterone is a hormone that thickens the lining of the uterus and prepares it for the growth and development of the baby. So, it helps your uterus grow during pregnancy and also prevents any contractions that can otherwise lead to miscarriage.
Uses of Proluton Depot 250mg/ml Injection
- Prevention of Premature Labor
Proluton Depot 250mg/ml Injection Side Effects
Safety Tips
Liver
UNSAFE
Proluton Depot 250mg/ml is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Proluton Depot 250mg/ml. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Proluton Depot 250mg/ml is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
Proluton Depot 250mg/ml is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Proluton Depot 250mg/ml in patients with kidney disease. Please consult your doctor.This medicine contains progesterone which can cause fluid retention in patients with underlying kidney disease.
Driving
SAFE
Proluton Depot 250mg/ml does not usually affect your ability to drive.
Quick Tips
- It is not for use in women who are pregnant with more than one baby (twins, triplets, etc.).
- Inform your doctor immediately if you have pain in the chest, groin or legs, difficulty with breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.
- Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. These could be symptoms of a serious liver problem.
- Proluton Depot 250mg/ml is used in pregnant women to help lower the risk of giving birth too early (preterm birth).
- It is only given to a woman who has had a preterm delivery in the past.
- It may affect blood sugar levels. Monitor your blood sugar regularly.
- It is administered only by or under the immediate supervision of your doctor. Your doctor can start giving you the injection every week between 16 and 20 weeks and continue through week 37, or until you deliver.
References
- Hydroxyprogesterone Caproate Injection [Prescribing Information]. Waltham, MA: AMAG Pharmaceuticals, Inc.; 2022.
- Hydroxyprogesterone Caproate Injection [Package Insert]. Ranipur, Uttarakhand: Akums Drugs & Pharmaceuticals Ltd.
- Drugs.com. Hydroxyprogesterone.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 671-72.
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198.
- Mayo Clinic. Hydroxyprogesterone.