Trexopar 15mg Injection
Product Info
| Prescription required | Yes |
| Marketer | Parenteral Drugs India Ltd |
| Active Ingredient | Methotrexate (15mg) |
| Storage | Store below 30°C |
| Chemical Class | Glutamic Acid Derivative |
| Habit Forming | No |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolite- Methotrexate |
| User Rating | 4.4 |
| User Reviews | 603 |
FAQ
Can Trexopar 15mg use make me more prone to infections?
Trexopar 15mg may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports which suggest occurrence of serious lung infections with Trexopar 15mg use. If you have an active infection, Trexopar 15mg should be used with extreme caution.
Why do I have to take folic acid with Trexopar 15mg?
Folic acid is required to make new cells in the body and Trexopar 15mg decreases the folic acid levels in the body. Folic acid can help reduce some of the common side effects of Trexopar 15mg such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems.
Why do I need to take regular blood tests while taking Trexopar 15mg?
Regular blood tests will help your doctor to check your response to Trexopar 15mg and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.
Can Trexopar 15mg cause mouth ulcers?
Yes, Trexopar 15mg can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.
What to do if I am planning to become pregnant and my husband is taking Trexopar 15mg?
You should avoid pregnancy if your husband is taking Trexopar 15mg. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.
Can Trexopar 15mg affect fertility?
Yes, Trexopar 15mg may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry, these effects are reversible and disappear once the therapy is discontinued.
Trexopar 15mg Injection Reviews
Trexopar 15mg is a medicine used to treat rheumatoid arthritis where it helps prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis, in the treatment of various cancers, and in the treatment of Crohn's disease.
Trexopar 15mg is given under the supervision of a doctor or a nurse and should not be self-administered. It may be used by itself or in combination with other medicines. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
The most common side effects of this medicine include abdominal pain, indigestion, los of appetite, nausea, vomiting, tiredness, hair loss, and low blood platelets. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is powerful medicine, and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you on regular blood tests to check for these.
Before taking it, tell your doctor if you are pregnant, have stomach, liver, or kidney problems, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine.
Trexopar 15mg is given under the supervision of a doctor or a nurse and should not be self-administered. It may be used by itself or in combination with other medicines. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
The most common side effects of this medicine include abdominal pain, indigestion, los of appetite, nausea, vomiting, tiredness, hair loss, and low blood platelets. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is powerful medicine, and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you on regular blood tests to check for these.
Before taking it, tell your doctor if you are pregnant, have stomach, liver, or kidney problems, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine.
How Trexopar 15mg Injection Works
Trexopar 15mg is an immunosuppressant. In rheumatoid arthritis and Crohn's disease, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells. In cancer, it inhibits cancer cells from multiplying by blocking a special enzyme that is needed to make new cells.
How to Use Trexopar 15mg Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Benefits of Trexopar 15mg Injection
- In Treatment of Rheumatoid arthritis: Trexopar 15mg belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment. It works by reducing the body's immune system, this decreases swelling, reduces pain, stiffness, and improves function. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.
- In Treatment of Psoriasis: Trexopar 15mg belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly. Trexopar 15mg works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
Uses of Trexopar 15mg Injection
- Treatment of Rheumatoid arthritis
- Treatment of Psoriasis
- Treatment of Cancer
- Treatment of Crohn’s disease
Trexopar 15mg Injection Side Effects
Safety Tips
Liver
CAUTION
Trexopar 15mg should be used with caution in patients with liver disease. Dose adjustment of Trexopar 15mg may be needed. Please consult your doctor.Use of Trexopar 15mg is not recommended in patients with severe liver disease.
Pregnancy
UNSAFE
Trexopar 15mg is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Driving
UNSAFE
Trexopar 15mg may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Alcohol
CAUTION
Caution is advised when consuming alcohol with Trexopar 15mg. Please consult your doctor.
Breast feeding
UNSAFE
Trexopar 15mg is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Kidney
CAUTION
Trexopar 15mg should be used with caution in patients with kidney disease. Dose adjustment of Trexopar 15mg may be needed. Please consult your doctor.Regular monitoring of kidney function test is advised while you are taking this medicine.
Quick Tips
- Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
- Take it once a week, on the same day every week.
- It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
- It may take 6 to 8 weeks for Trexopar 15mg to work. Keep taking the medication as prescribed.
- Drink plenty of liquids to stay hydrated while taking this medication.
- It is given as an injection under the skin (subcutaneously), usually in the upper thigh or the abdomen.
- Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
References
- Central Drugs Standard Control Organisation. Manufacturing and Marketing permission issued from SND Division from 01.01.2018 to 28.09.2018.
- Rampton DS. Methotrexate in Crohn's disease. Gut. 2001 Jun;48(6):790-1.
- CiplaMed. Methotrexate [Prescribing Information]. Last Reviewed: Feb 2019].
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
- Hanoodi M, Mittal M. Methotrexate. [Updated 2023 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.