Apresol Plus Tablet


Product Info

Prescription required Yes
Marketer Ordain Health Care Global Pvt Ltd
Active Ingredient Isosorbide Dinitrate (20mg) + Hydralazine (37.5mg)
Storage Store below 30°C
Habit FormingNo
Therapeutic ClassCARDIAC
User Rating4.2
User Reviews579

FAQ

Question
Can I stop taking Apresol Plus if I feel well?
No, keep using Apresol Plus as advised by your doctor, even if you feel well. Stopping Apresol Plus suddenly may lead to serious complications of heart failure.
Answer

Question
Can the use of Apresol Plus cause dizziness?
Yes, the use of Isosorbide Apresol Plus can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Answer

Question
Can the use of Apresol Plus cause headache?
Apresol Plus can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.
Answer

Question
Are there any special instructions regarding storage and disposal of this medicine?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Answer
Question
What if you forget to take Apresol Plus?
If you miss a dose of Apresol Plus, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Answer

Apresol Plus Tablet Reviews

Apresol Plus is used in the treatment of heart failure. It is a combination of two medicines that effectively control symptoms of heart failure.

Apresol Plus should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like a low-fat diet, exercise, and not smoking may help this medicine to work better.

It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, low blood pressure, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from a sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.

Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.

How Apresol Plus Tablet Works

Apresol Plus is a combination of two medicines:.

How to Use Apresol Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apresol Plus is to be taken with food.

Benefits of Apresol Plus Tablet

  • In Treatment of Heart failure: Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Apresol Plus makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure.This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes, such as eating healthy and keeping active, to help this medicine be effective. Take it regularly and keep taking it even if you feel better.

Uses of Apresol Plus Tablet

  • Treatment of Heart failure

Apresol Plus Tablet Side Effects

Item form

Safety Tips

Kidney  CAUTION
Apresol Plus should be used with caution in patients with severe kidney disease. Dose adjustment of Apresol Plus may be needed. Please consult your doctor.Regular monitoring of blood pressure is recommended for better dose adjustment.
Alcohol  UNSAFE
Consuming alcohol while taking Apresol Plus may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy  CONSULT YOUR DOCTOR
Apresol Plus may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding  SAFE IF PRESCRIBED
Apresol Plus is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving  UNSAFE
Apresol Plus may cause side effects which could affect your ability to drive.As Apresol Plus may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Liver  SAFE IF PRESCRIBED
Apresol Plus is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Apresol Plus may not be needed in these patients. Please consult your doctor.

Quick Tips

  • It is best to avoid drinking alcohol while taking Apresol Plus as it may make the side effects worse.
  • Apresol Plus is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
  • This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
  • Do not stop taking Apresol Plus suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.
  • Apresol Plus may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Do not take it in combination with  medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.

References

  1. ScienceDirect. Isosorbide Dinitrate.
  2. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9.
  3. Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015].
  4. Isosorbide dinitrate and hydralazine hydrochloride [Prescribing Inforamtion]. Seymour, IN: Kremers Urban Pharmaceuticals Inc.; 2015.
  5. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78.
  6. Central Drugs Standard Control Organization. Isosorbide Dinitrate+Hydralazine.
  7. Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48.

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