Dermotrex 2.5mg Tablet
Product Info
| Prescription required | Yes |
| Marketer | East West Pharma |
| Active Ingredient | Methotrexate (2.5mg) |
| Storage | Store below 30°C |
| Chemical Class | Glutamic Acid Derivative |
| Habit Forming | No |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolite- Methotrexate |
| User Rating | 4.3 |
| User Reviews | 793 |
FAQ
Can Dermotrex 2.5mg affect fertility?
Yes, Dermotrex 2.5mg may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry, these effects are reversible and disappear once the therapy is discontinued.
Why do I have to take folic acid with Dermotrex 2.5mg?
Folic acid is required to make new cells in the body and Dermotrex 2.5mg decreases the folic acid levels in the body. Folic acid can help reduce some of the common side effects of Dermotrex 2.5mg such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems.
What to do if I am planning to become pregnant and my husband is taking Dermotrex 2.5mg?
You should avoid pregnancy if your husband is taking Dermotrex 2.5mg. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.
Can Dermotrex 2.5mg cause mouth ulcers?
Yes, Dermotrex 2.5mg can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.
Why do I need to take regular blood tests while taking Dermotrex 2.5mg?
Regular blood tests will help your doctor to check your response to Dermotrex 2.5mg and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.
Can Dermotrex 2.5mg use make me more prone to infections?
Dermotrex 2.5mg may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports which suggest occurrence of serious lung infections with Dermotrex 2.5mg use. If you have an active infection, Dermotrex 2.5mg should be used with extreme caution.
What if you forget to take Dermotrex Tablet?
If you miss a dose of Dermotrex 2.5mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Dermotrex 2.5mg Tablet Reviews
Dermotrex 2.5mg is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease.
Dermotrex 2.5mg may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid consumption of alcohol while taking this medicine as it may increase your risk of liver damage.
The most common side effects of this medicine are ulcerative stomatitis, hairloss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine to check for these.
Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidney, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding as it may harm the baby.
Dermotrex 2.5mg may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid consumption of alcohol while taking this medicine as it may increase your risk of liver damage.
The most common side effects of this medicine are ulcerative stomatitis, hairloss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine to check for these.
Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidney, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding as it may harm the baby.
How Dermotrex 2.5mg Tablet Works
Dermotrex 2.5mg inhibits enzymes (dihydrofolate reductase), prevents cell division and leads to anti-inflammatory actions. Dermotrex 2.5mg kills cancer cells by preventing them from making DNA. Dermotrex 2.5mg can help control psoriasis by retarding the production of skin cells and suppressing inflammation. Dermotrex 2.5mg may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body's cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis, or damage to bowel in Crohn's disease.
How to Use Dermotrex 2.5mg Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dermotrex 2.5mg may be taken with or without food, but it is better to take it at a fixed time.
Benefits of Dermotrex 2.5mg Tablet
- In Treatment of Psoriasis: Dermotrex 2.5mg belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly. Dermotrex 2.5mg works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
- In Treatment of Cancer: Dermotrex 2.5mg works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
- In Treatment of Rheumatoid arthritis: Dermotrex 2.5mg belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment. It works by reducing the body's immune system, this decreases swelling, reduces pain, stiffness, and improves function. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.
- In Treatment of Crohn’s disease: Crohn’s disease is a chronic (long-term) inflammatory disease of the intestines. The most common symptoms are diarrhea and pain in your abdomen. Dermotrex 2.5mg helps reduce the inflammation, relieve the symptoms, and prevent them from coming back.
Uses of Dermotrex 2.5mg Tablet
- Treatment of Crohn’s disease
- Treatment of Psoriasis
- Treatment of Rheumatoid arthritis
- Treatment of Cancer
Dermotrex 2.5mg Tablet Side Effects
Safety Tips
Driving
UNSAFE
Dermotrex 2.5mg may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Breast feeding
UNSAFE
Dermotrex 2.5mg is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Kidney
CAUTION
Dermotrex 2.5mg should be used with caution in patients with kidney disease. Dose adjustment of Dermotrex 2.5mg may be needed. Please consult your doctor.Regular monitoring of kidney function test is advised while you are taking this medicine.
Pregnancy
UNSAFE
Dermotrex 2.5mg is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Alcohol
UNSAFE
It is unsafe to consume alcohol with Dermotrex 2.5mg.
Liver
CAUTION
Dermotrex 2.5mg should be used with caution in patients with liver disease. Dose adjustment of Dermotrex 2.5mg may be needed. Please consult your doctor.
Quick Tips
- It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
- Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
- Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
- It may take from weeks to months for Dermotrex 2.5mg to work. Keep taking the medication as prescribed.
- Drink plenty of liquids to stay hydrated while taking this medication.
- Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.
References
- Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
- CiplaMed. Methotrexate [Prescribing Information]. [Last Reviewed: Feb 2019].
- Walfish AE, Companioni RA. Drugs for Inflammatory Bowel Disease. [Updated Sep. 2022].
- Methotrexate [Product Label]. New York, NY: Pfizer Inc.; 2022.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
- Methotrexate [Prescribing Information]. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020.
- Crohn's & Colitis, UK. Methotrexate [Information Sheet].