Glyson-MF Tablet
Product Info
| Prescription required | Yes |
| Marketer | Unison Pharmaceuticals Pvt Ltd |
| Active Ingredient | Glipizide (5mg) + Metformin (500mg) |
| Storage | Store below 30°C |
| Habit Forming | No |
| Therapeutic Class | ANTI DIABETIC |
| User Rating | 4.8 |
| User Reviews | 699 |
FAQ
What is Glyson-MF?
Glyson-MF is a combination of two medicines: Glipizide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glipizide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.
Can the use of Glyson-MF cause hypoglycemia?
Yes, the use of Glyson-MF can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always carry some glucose tablets, honey or fruit juice with you.
Is it safe to take alcohol while I am also taking Glyson-MF?
No, it is not safe to take Glyson-MF along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
What is Glyson-MF?
Glyson-MF is a combination of two medicines: Glipizide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glipizide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.
Is it safe to take alcohol while I am also taking Glyson-MF?
No, it is not safe to take Glyson-MF along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
Can the use of Glyson-MF cause hypoglycemia?
Yes, the use of Glyson-MF can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always carry some glucose tablets, honey or fruit juice with you.
Can the use of Glyson-MF cause lactic acidosis?
Yes, the use of Glyson-MF can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glyson-MF and immediately consult your doctor.
What are the instructions for storage and disposal of Glyson-MF?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Can the use of Glyson-MF cause lactic acidosis?
Yes, the use of Glyson-MF can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glyson-MF and immediately consult your doctor.
What are the possible side effects of Glyson-MF?
The use of Glyson-MF is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.
Can the use of Glyson-MF lead to Vitamin B12 deficiency?
Yes, the use of Glyson-MF can cause Vitamin B12 deficiency on long-term use. It interferes with absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can feel a tingling sensation and numbness in the hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.
What are the possible side effects of Glyson-MF?
The use of Glyson-MF is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.
Are there any specific conditions in which Glyson-MF should not to be taken?
The use of Glyson-MF should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
Can the use of Glyson-MF lead to Vitamin B12 deficiency?
Yes, the use of Glyson-MF can cause Vitamin B12 deficiency on long-term use. It interferes with absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can feel a tingling sensation and numbness in the hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.
What are the instructions for storage and disposal of Glyson-MF?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Are there any specific conditions in which Glyson-MF should not to be taken?
The use of Glyson-MF should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
What if you forget to take Glyson-MF?
If you miss a dose of Glyson-MF, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Glyson-MF Tablet Reviews
Glyson-MF belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.
Glyson-MF should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Glyson-MF is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, edema (swelling), blurred vision, bone fracture, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
How Glyson-MF Tablet Works
Glipizide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
How to Use Glyson-MF Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glyson-MF is to be taken with food.
Glyson-MF Tablet Side Effects
Safety Tips
Breast feeding
CONSULT YOUR DOCTOR
Glyson-MF is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Kidney
CAUTION
Glyson-MF should be used with caution in patients with kidney disease. Dose adjustment of Glyson-MF may be needed. Please consult your doctor.Use of Glyson-MF is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Alcohol
UNSAFE
It is unsafe to consume alcohol with Glyson-MF.
Liver
CAUTION
Glyson-MF should be used with caution in patients with liver disease. Dose adjustment of Glyson-MF may be needed. Please consult your doctor.Glyson-MF is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Pregnancy
CONSULT YOUR DOCTOR
Glyson-MF may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Quick Tips
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
- Monitor your blood sugar level regularly while you are taking this medicine.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glyson-MF may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glyson-MF may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Monitor your blood sugar level regularly while you are taking this medicine.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
References
- Glipizide and Metformin Hydrochloride. Ahmedabad, India: Cadila Healthcare Ltd; 2016.
- Medscape. Glipizide/Metformin.
- Glipizide and metformin [Drug Label]. Princeton, NJ: Bristol-Myers Squibb Company: 2008.
- Glipizide+metformin HCl. Princeton, New Jersey: Bristol-Myers Squibb Company.
- American Diabetes Association. 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S200-S210.