Jakmac-ER Tablet
Product Info
| Prescription required | Yes |
| Marketer | Macleods Pharmaceuticals Pvt Ltd |
| Active Ingredient | Tofacitinib (11mg) |
| Chemical Class | Pyrrolo Pyrimidine Derivative |
| Habit Forming | No |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Janus kinase inhibitors |
| User Rating | 4.9 |
| User Reviews | 645 |
FAQ
Do I need to get any investigations done before starting Jakmac-ER?
You may need to get your blood tests done before you start Jakmac-ER or while you are taking it. Blood tests are done in order to check if you have a low red blood cell count (anemia), low white blood cell count (neutropenia or lymphopenia), high blood fat (cholesterol) or high levels of liver enzymes. It also helps to ensure that treatment with Jakmac-ER is not causing problems. In addition to this, your doctor may advise you to get tested for tuberculosis before starting Jakmac-ER, as using Jakmac-ER may make an existing infection worse.
If I am already taking tocilizumab, can I take Jakmac-ER?
No, you should not take tocilizumab along with Jakmac-ER. Jakmac-ER affects the immune system, so you should avoid taking it with any other immunity-affecting medicine. Taking both medicines together can further increase the risk of infection and may lead to further complications.
Can Jakmac-ER cause cancer?
Jakmac-ER may increase the chances of developing the risk of certain cancers (lymphoma and other cancers including skin cancers) by affecting the working of the immune system. Hence, inform your doctor if you ever had or have any type of cancer.
How long does it take for Jakmac-ER to start working?
Jakmac-ER usually takes about 2 to 8 weeks before you start feeling better, and it can take 3 to 6 months to feel the maximum effect of this medication.
Can Jakmac-ER cause infections?
Jakmac-ER is a medicine that affects your immune system. This may reduce your ability to fight infection and may increase the risk of getting a serious infection including tuberculosis. It may also include infections caused by severe fungal, bacterial or viral infections that spread through the body. In some cases, these infections can be life-threatening and may even cause death. Hence, it is advised to treat these infections in a hospital.
Can I take Jakmac-ER if I have liver problems?
Inform your doctor if you have liver problems, before starting Jakmac-ER. This is done because in some cases Jakmac-ER may cause an increase in liver enzymes. Therefore, your liver function needs to be investigated before starting Jakmac-ER. Although, Jakmac-ER can be given to patients with mild to moderate liver function impairment, but should not be prescribed to patients with severe liver impairment.
What is Jakmac-ER used for?
Jakmac-ER is approved for use in people with moderate to severe rheumatoid arthritis. It is an inflammatory disease of the joints. It is used if previous therapy did not work well or did not suit the patient. However, it can also be used earlier in treatment if the person does not respond well to the prescribed drugs. It can be used alone or together with some other medicines, such as methotrexate.
What if you forget to take Jakmac Tablet ER?
If you miss a dose of Jakmac-ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Jakmac-ER Tablet Reviews
Jakmac-ER is used to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. It helps decrease pain, tenderness, and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage.
Jakmac-ER may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.
The most common side effects of Jakmac-ER include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.
You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Jakmac-ER can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.
Jakmac-ER may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.
The most common side effects of Jakmac-ER include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.
You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Jakmac-ER can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.
How Jakmac-ER Tablet Works
Jakmac-ER is a Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases the activity of the immune system and inflammation associated with rheumatic diseases and ulcerative colitis.
How to Use Jakmac-ER Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Jakmac-ER may be taken with or without food, but it is better to take it at a fixed time.
Benefits of Jakmac-ER Tablet
- In Treatment of Rheumatoid arthritis: Jakmac-ER works by blocking the action of some chemicals which cause inflammation. It can help reduce pain, stiffness, and swelling in your joints and slow down the progression of bone and joint damage. This will help you do normal daily activities more easily and thus improve your quality of life. This medicine should be taken at the same time each day to get maximum benefits. Keep taking the medicine even if you feel well because it is preventing future harm as well as improving your symptoms.
- In Treatment of Ulcerative colitis: Ulcerative colitis is a disease of the large intestine (colon) and rectum in which the lining of the bowel becomes red and swollen. This can lead to bleeding, frequent diarrhea and abdominal pain. It relieves these symptoms and also helps you to stay well by preventing them from coming back. Drink plenty of fluids while on treatment with this medicine and stay hydrated.
- In Treatment of Ankylosing spondylitis: Ankylosing spondylitis is a rare type of arthritis that affects the spine or larger joints. It usually starts in your lower back and can spread up to your neck or damage joints in other parts of your body. Jakmac-ER helps reduce pain, stiffness and swelling in your spine and joints. It helps improve flexibility and prevents disease progression. This will help you lead a better and active life.
- In Treatment of Psoriatic arthritis: Psoriatic arthritis is a form of arthritis that affects some people who have psoriasis, a condition where the skin cells in the body grow too quickly and form scales and dry patches. Psoriatic arthritis is a type of inflammatory arthritis. Symptoms include joint pain, stiffness and swelling, which may flare and subside. Jakmac-ER helps reduce pain, stiffness, and swelling associated with the condition. It also helps improve flexibility and prevents the disease progression. This way it helps in the management of psoriatic arthritis and enhances patients' quality of life.
Uses of Jakmac-ER Tablet
- Treatment of Psoriatic arthritis
- Treatment of Ankylosing spondylitis
- Treatment of Rheumatoid arthritis
- Treatment of Ulcerative colitis
Jakmac-ER Tablet Side Effects
Safety Tips
Driving
SAFE
Jakmac-ER does not usually affect your ability to drive.
Kidney
CAUTION
Jakmac-ER should be used with caution in patients with severe kidney disease. Dose adjustment of Jakmac-ER may be needed. Please consult your doctor.
Alcohol
SAFE
Consuming alcohol with Jakmac-ER does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Jakmac-ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Jakmac-ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Liver
CAUTION
Jakmac-ER should be used with caution in patients with severe liver disease. Dose adjustment of Jakmac-ER may be needed. Please consult your doctor.
Quick Tips
- Jakmac-ER is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs.
- It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed.
- Jakmac-ER can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
- Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels.
- Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.
References
- Tofacitinib. New York, New York: Pfizer Labs; 2012 [revised Nov. 2012].
- Central Drugs Standard Control Organisation (CDSCO). Tofacitinib.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1373-74.
- Tofacitinib [Prescribing Information]. New York, NY: Pfizer labs; 2022.