Libset Tablet

Reviews How to Use Benefits Uses Side Effects

Product Info

Prescription required	Yes
Marketer	Intas Pharmaceuticals Ltd
Active Ingredient	Lapatinib (250mg)
Storage	Store below 30°C
Chemical Class	Quinazolinamines Derivative
Habit Forming	No
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Tyrosine kinase inhibitors
User Rating	5.0
User Reviews	353

FAQ

How should I manage diarrhea while taking Libset?

If you suffer from diarrhea while taking Libset, you should drink plenty of fluids (8 to 10 glasses a day) such as water, sports drinks, or other clear liquids. You should eat low-fat, high protein foods instead of fatty or spicy foods. Eating cooked vegetables instead of raw vegetables and removing the skin from fruits before eating can also be helpful. Try to avoid milk and milk products (including ice cream) and herbal supplements (some may cause diarrhoea). Inform the doctor, if the condition persists, who may interrupt the treatment depending on the severity of diarrhea.

How can I take care of my skin while on Libset?

Your doctor will check your skin before and during the treatment. If you have sensitive skin, use a soap-free cleanser and beauty products that are fragrance-free and hypoallergenic. It is also advised that you use sunscreen with an SPF (Sun Protection Factor) of 30 or higher. Inform your doctor immediately if you get a rash.

How should I take Libset?

You should take Libset exactly as advised by your doctor. Swallow Libset tablets whole with a glass of water, at the same time each day. You must take Libset 1 hour before or 1 hour after meals and at the same time concerning food each day (e.g., you could always take your tablet one hour before breakfast).

What tests will the doctor advise before starting Libset?

You may need extra tests to check that your heart and liver are working properly. Libset may change the way your heart beats and pumps blood through your body. Your doctor will monitor you carefully to see whether Libset has affected your heart. Along with that, your doctor will get your liver function investigated. Based on the results of these tests, the doctor will decide whether dose adjustment or discontinuation of treatment is required.

How long after Libset can I plan pregnancy?

Use an effective method of contraception to avoid pregnancy while you are taking Libset and continue for at least 1 week after the last dose. Inform your doctor if you become pregnant, who will decide whether to stop or continue treatment.

Does Libset have any effect on liver?

Libset may cause liver damage which can be severe or life-threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with Libset. Inform your doctor if you have or had liver disease. If you experience any of the symptoms such as itching, change in color of the skin or eyes (yellowing), discoloration of urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools, call your doctor immediately.

Is Libset a chemotherapy medicine?

No, this is a targeted drug that belongs to a class of anti-cancer medicines. They are more specific than chemotherapy in their mechanisms of action. Libset belongs to the tyrosine kinase inhibitors group of medicines. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Can Libset be given in combination with other anti-cancer drug?

Yes, Libset can be used with other anti-cancer drugs. Generally, it is used in combination with capecitabine to treat advanced breast cancer in patients who have already been treated with chemotherapy. Libset is also used with letrozole to treat breast cancer in post-menopausal women.

What if you forget to take Libset?

If you miss a dose of Libset, consult your doctor.

Libset Tablet Reviews

Libset is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced-stage breast cancer.

Libset should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine.

Before taking Libset, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

How Libset Tablet Works

Libset is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.

How to Use Libset Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Libset is to be taken empty stomach.

Benefits of Libset Tablet

In Breast cancer: Libset helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. It relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipples or changes in the shape or texture of the breast. Libset kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Discuss with your doctor if any of the side effects bother you.

Uses of Libset Tablet

Breast cancer

Libset Tablet Side Effects

Safety Tips

Kidney ^CAUTION

Libset should be used with caution in patients with severe kidney disease. Dose adjustment of Libset may be needed. Please consult your doctor.Limited information is available on the use of Libset in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Alcohol ^{CONSULT YOUR DOCTOR}

It is not known whether it is safe to consume alcohol with Libset. Please consult your doctor.

Driving ^UNSAFE

Libset may cause side effects which could affect your ability to drive.

Pregnancy ^{CONSULT YOUR DOCTOR}

Libset is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Liver ^CAUTION

Libset should be used with caution in patients with liver disease. Dose adjustment of Libset may be needed. Please consult your doctor.Limited information is available on the use of this medicine in patients with the severe liver disease.

Breast feeding ^UNSAFE

Libset is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Quick Tips

Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
It should be taken 1 hour before or 2 hours after the meal, preferably at the same time every day.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737-38.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 779-80.
Lapatinib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2007 [revised Mar. 2015].
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Lapatinib. [Updated 2019 Jan 7].
Central Drugs Standard Control Organisation (CDSCO).
Lapatinib ditosylate monohydrate. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2008 [revised 13 Dec. 2018].