Pazobrite 400mg Tablet
Product Info
| Prescription required | Yes |
| Marketer | Torrent Pharmaceuticals Ltd |
| Active Ingredient | Pazopanib (400mg) |
| Storage | Store below 30°C |
| Chemical Class | Alkyldiarylamines Derivative |
| Habit Forming | No |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| User Rating | 4.1 |
| User Reviews | 440 |
FAQ
How will I know if Pazobrite 400mg is helping me?
The duration for which you have to continue taking Pazobrite 400mg varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.
What is the most important information I need to know about Pazobrite 400mg?
Pazobrite 400mg may cause severe or life-threatening liver damage. Inform your doctor if you have or had liver disease. If you experience any of the following symptoms such as discoloration of the skin or eyes (yellowing), dark urine, extreme tiredness, nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, or unusual bleeding or bruising, call your doctor immediately. Your doctor may ask you to take some lab tests before you start taking Votrient. After you start taking Votrient, you may need to take those lab tests at weeks 3, 5, 7 and 9 and then at months 3 and 4. Your doctor may also prescribe additional tests if necessary. Periodic testing should then continue after 4 months.
Are there any food restrictions while I’m taking Pazobrite 400mg?
Yes, it is best to avoid grapefruit and grapefruit juice while on Pazobrite 400mg, as it may affect how the medicine works in your body. Ask your doctor about any additional foods you should avoid.
How should I take Pazobrite 400mg?
Pazobrite 400mg should be taken orally by mouth once a day or as directed by your doctor. Swallow the tablets whole with water, do not break or crush the tablets. This affects the way the medicine is absorbed and may increase the chance of side effects.
How long I have to take Pazobrite 400mg?
The duration for which you have to continue taking Pazobrite 400mg varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.
Is Pazobrite 400mg a chemotherapy medicine?
Pazobrite 400mg is not a conventional chemotherapy medicine. It belongs to a class of medicine called a protein kinase inhibitor. Pazobrite 400mg works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.
Can Pazobrite 400mg be taken with food?
Pazobrite 400mg should be taken on an empty stomach, at least 1 hour before or 2 hours after food. If it is taken with food, the dosage may need to be increased. Doing this will in turn cause more side effects.
Pazobrite 400mg Tablet Reviews
Pazobrite 400mg is a protein kinase inhibitor used in the treatment of kidney cancer and soft tissue sarcoma.
Pazobrite 400mg should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Diarrhea and high blood pressure are the most common side effects of this medicine. Doctor may advise for regular monitoring of your blood pressure while on treatment. Drink plenty of fluids to overcome diarrhea or consult with your doctor if it bothers you. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you experience fever, flu-like symptoms and shortness of breath.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Pazobrite 400mg should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Diarrhea and high blood pressure are the most common side effects of this medicine. Doctor may advise for regular monitoring of your blood pressure while on treatment. Drink plenty of fluids to overcome diarrhea or consult with your doctor if it bothers you. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you experience fever, flu-like symptoms and shortness of breath.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
How Pazobrite 400mg Tablet Works
Pazobrite 400mg is an anti-cancer medication. It works by binding and inhibiting the enzyme receptors (tyrosine kinase) that are responsible for the proliferation of the cancerous cells. It also restricts the growth of new blood vessels within the tumor. This is how it works against cancer.
How to Use Pazobrite 400mg Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pazobrite 400mg is to be taken empty stomach.
Benefits of Pazobrite 400mg Tablet
- In Soft tissue sarcoma: Soft tissue sarcoma is a type of sarcoma that develops in tissues such as bone and muscles. Pazobrite 400mg kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Follow your doctor’s instructions carefully and let your doctor know if any of the side effects bother you.
- In Kidney cancer: Pazobrite 400mg is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.
Uses of Pazobrite 400mg Tablet
- Kidney cancer
- Soft tissue sarcoma
Pazobrite 400mg Tablet Side Effects
Safety Tips
Kidney
SAFE IF PRESCRIBED
Pazobrite 400mg is safe to use in patients with kidney disease. No dose adjustment of Pazobrite 400mg is recommended.
Driving
UNSAFE
Pazobrite 400mg may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Liver
CAUTION
Pazobrite 400mg should be used with caution in patients with liver disease. Dose adjustment of Pazobrite 400mg may be needed. Please consult your doctor.Use of Pazobrite 400mg is not advised in patients with moderate to severe liver disease.
Pregnancy
CONSULT YOUR DOCTOR
Pazobrite 400mg is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Pazobrite 400mg. Please consult your doctor.
Breast feeding
UNSAFE
Pazobrite 400mg is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
References
- Pazopanib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2009 [revised Apr. 2012].
- Central Drugs Standard Control Organisation (CDSCO).
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1072-73.