Zyloric 300 Tablet

Reviews How to Use Benefits Uses Side Effects

Product Info

Prescription required	Yes
Marketer	Glaxo SmithKline Pharmaceuticals Ltd
Active Ingredient	Allopurinol (300mg)
Storage	Store below 30°C
Chemical Class	Pyrazolo Pyrimidine Derivative
Habit Forming	No
Therapeutic Class	PAIN ANALGESICS
Action Class	Xanthine oxidase Inhibitors-gout
User Rating	4.7
User Reviews	663

FAQ

What is the best time of the day to take Zyloric 300?

Zyloric 300 can be taken at anytime of the day but preferably should be taken at the same time each day so that you remember to take it. It is usually prescribed once daily and should be taken after meals. If the dose exceeds 300 mg or if your stomach is upset, you can take it in divided doses as advised by your doctor.

Why do I still get gout while taking Zyloric 300?

If you have started taking Zyloric 300, you may experience an increase in attacks of gout (severe pain, swelling, and redness). However, these attacks usually become shorter and less severe after several months of therapy. The possible reason for increased attacks could be gradual breakdown of uric acid crystals, causing fluctuations in uric acid levels in the blood. To prevent such painful events, your doctor may advise to take colchicine with Zyloric 300, as it can suppress the gouty attacks.

What if I take alcohol while taking Zyloric 300?

You should refrain yourself from consuming alcohol while taking Zyloric 300 as this could make your condition worse. Also, you should avoid all foods that are rich source of proteins as it will help to prevent attacks of gout. Consult your doctor for a detailed list of food items which need to be avoided. It is also recommended that you drink at least 8 glasses of water or other fluids while taking Zyloric 300, unless your doctor has advised otherwise.

How long does it take for Zyloric 300 to lower uric acid levels?

It may take several months before you start feeling better or notice any significant reduction in attacks of gout (severe pain, swelling, and redness). Initially after starting Zyloric 300 you may experience gouty attacks. Continue taking Zyloric 300 even if you do not experience any considerable relief from the attacks. Do not stop taking Zyloric 300 without consulting your doctor. Your doctor will prescribe you another medicine along with Zyloric 300 to prevent the initial attacks. It may take up to years for the body to completely get rid of all uric acid crystals.

Does Zyloric 300 cause drowsiness?

Yes, Zyloric 300 may cause drowsiness in some people. It can even make you feel giddy (dizzy) or you may have problems with coordination. It would be best to avoid driving or operating machinery if you experience these side effects. However, if it is unavoidable then extreme caution should be exercised while performing such tasks.

What if you forget to take Zyloric Tablet?

If you miss a dose of Zyloric 300, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Zyloric 300 Tablet Reviews

Zyloric 300 is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals that can appear around your joints and kidneys and cause pain. This medicine helps to keep uric acid levels low.

Zyloric 300 should be taken after food. You should keep taking it as recommended by your doctor even when you are not having a gout attack. If you stop, your symptoms may get worse because more crystals form in your joints and kidneys. You can help yourself by making some changes to your diet and drinking plenty of fluids.

Some of the common side effects of this medicine are nausea, diarrhea, increased serum glutamic oxaloacetic transaminase and serum glutamate pyruvate transaminase, and increased alkaline phosphatase. Your doctor may help with ways to reduce or prevent these symptoms. Some people may get a severe allergic reaction that needs urgent medical attention. Talk to your doctor straight away if you get symptoms of liver disease including nausea that does not stop, yellowing skin or eyes, or dark urine.

To make sure it is safe for you, before taking this medicine, let your doctor know if you have or have had heart failure, heart problems, stroke, kidney or liver disease, or thyroid problems. Do not use this medicine if you are pregnant or breastfeeding. Check with your doctor. You will be asked for regular blood tests to check that your liver is working properly.

How Zyloric 300 Tablet Works

Zyloric 300 is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.

How to Use Zyloric 300 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zyloric 300 is to be taken with food.

Benefits of Zyloric 300 Tablet

In Treatment of Gout: Zyloric 300 is used to prevent and treat gout. Gout is caused by too much uric acid in your body. When the level becomes too high, crystals may form in and around certain joints and your kidneys. This can cause sudden and severe pain, redness, warmth, and swelling. This medicine works by preventing crystals from forming and reducing the levels of uric acid in your blood. This makes it less likely that you will suffer the symptoms and make them milder if you do have them. It is usually for long-term treatment and should be taken regularly until the dose is completed.

Uses of Zyloric 300 Tablet

Treatment of Gout

Zyloric 300 Tablet Side Effects

Safety Tips

Driving ^UNSAFE

Zyloric 300 may cause side effects which could affect your ability to drive.Occasionally drowsiness, dizziness or vertigo, ataxia and visual disturbances, may occur when taking Zyloric 300. This may affect your driving ability.

Kidney ^CAUTION

Zyloric 300 should be used with caution in patients with kidney disease. Dose adjustment of Zyloric 300 may be needed. Please consult your doctor.

Alcohol ^CAUTION

Caution is advised when consuming alcohol with Zyloric 300. Please consult your doctor.

Pregnancy ^{CONSULT YOUR DOCTOR}

Zyloric 300 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Liver ^CAUTION

Zyloric 300 should be used with caution in patients with liver disease. Dose adjustment of Zyloric 300 may be needed. Please consult your doctor.

Breast feeding ^{CONSULT YOUR DOCTOR}

Zyloric 300 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Quick Tips

Take plenty of fluids (2-3 litres) daily while on Zyloric 300.
Take Zyloric 300 with food to avoid stomach upset.
Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
When you first start taking this medicine, you might have more gout attacks. Do not stop Zyloric 300 on having an acute attack of gout as that could make an attack worse.
Notify your doctor if you develop a rash. This could be a sign of allergy and should go away on discontinuing Zyloric 300.
Your doctor has prescribed Zyloric 300 to reduce episodes of gout attack.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 638-39.
CiplaMed. Allopurinol [Prescribing Information].
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198.
Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 996-97.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 40-42.