Zypara 1000mg Tablet SR
Product Info
| Prescription required | Yes |
| Marketer | Zydus Cadila |
| Active Ingredient | Pyrazinamide (1000mg) |
| Chemical Class | Nicotinic acid derivatives |
| Habit Forming | No |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Mycobacterial fatty acid synthase |
| User Rating | 4.5 |
| User Reviews | 626 |
FAQ
How does Zypara 1000mg cause hyperuricemia and gout?
Following oral intake of Zypara 1000mg, it gets converted in the body to pyrazinoic acid (active chemical form of Zypara 1000mg). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
How does Zypara 1000mg work/treat tuberculosis?
Zypara 1000mg kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Zypara 1000mg is not known
What is Zypara 1000mg and what is it used for?
Zypara 1000mg is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Is Zypara 1000mg bactericidal?
Zypara 1000mg is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
What if you forget to take Zypara Tablet SR?
If you miss a dose of Zypara 1000mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Zypara 1000mg Tablet SR Reviews
Zypara 1000mg is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body.
Zypara 1000mg is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.
Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.
Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.
Zypara 1000mg is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.
Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.
Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.
How Zypara 1000mg Tablet SR Works
Zypara 1000mg is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.
How to Use Zypara 1000mg Tablet SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zypara 1000mg may be taken with or without food, but it is better to take it at a fixed time.
Benefits of Zypara 1000mg Tablet SR
- In Tuberculosis (TB): Zypara 1000mg is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.
Uses of Zypara 1000mg Tablet SR
- Tuberculosis (TB)
Zypara 1000mg Tablet SR Side Effects
Safety Tips
Kidney
CAUTION
Zypara 1000mg should be used with caution in patients with severe kidney disease. Dose adjustment of Zypara 1000mg may be needed. Please consult your doctor.Kidney function tests are advised before you start taking this medicine.
Liver
CAUTION
Zypara 1000mg should be used with caution in patients with liver disease. Dose adjustment of Zypara 1000mg may be needed. Please consult your doctor.Regular monitoring of liver function tests is advised before and after the start of the treatment.
Driving
CONSULT YOUR DOCTOR
It is not known whether Zypara 1000mg alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Breast feeding
SAFE IF PRESCRIBED
Zypara 1000mg is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Pregnancy
CONSULT YOUR DOCTOR
Zypara 1000mg may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Alcohol
CAUTION
Caution is advised when consuming alcohol with Zypara 1000mg. Please consult your doctor.
Quick Tips
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Avoid drinking alcohol while taking Zypara 1000mg as this may increase the risk of side effects on the liver.
- Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
- Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Zypara 1000mg as it may make hormonal contraceptives such as the pill less effective.
- Zypara 1000mg along with other medications effectively treats tuberculosis.
References
- Drugs.com. Pyrazinamide.
- Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1554-555.
- Central Drugs Standard Control Organisation (CDSCO).
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198
- Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 827.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1171-72.